34 RELATIONSHIP BETWEEN SERUM CAROTENOID CONCENTRATIONS AND FRAILTY, PROBABLE SARCOPENIA, AND PHYSICAL FUNCTION IN THE IRISH LONGITUDINAL STUDY ON AGEING (TILDA)

Abstract Background Lutein and zeaxanthin are antioxidant anti-inflammatory carotenoids derived from foods such as fruit vegetables. Serum concentrations of (Ls) Zeaxanthin (Zs) reflect habitual dietary intake. This study examined the cross-sectional longitudinal relationships between Ls Zs frailty, probable sarcopenia, indices physical function in TILDA. Methods The analysis included n=4672 community-dwelling adults aged ≥50 years with at Wave 1 (2010). For analyses, changes usual gait speed (at 3, 2014), grip strength (Wave 4, 2016) Timed Up-and-Go (TUG; 5, 2018), incident sarcopenia (defined <27 kg men, <16 women, 4) frailty (Fried, 5) were determined. Multivariable linear logistic regression analyses adjusted for age, sex, waist circumference, education, malnutrition, smoking, chronic disease, alcohol intake activity. Results Cross-sectionally, positively associated (B [95% CI] per 100-nmol/L higher concentration: 0.67 [0.22, 1.12], 1.3 [0.21, 2.48] cm/s) inversely TUG time (Ls –0.07 [-0.11, –0.02], –0.14 [-0.25, –0.03] s) (OR: 0.61 [0.42, 0.87], 0.23 [0.08, 0.68]), all p <0.05), but not or sarcopenia. Longitudinally, was (OR 0.85 [0.04, 0.84], p=0.03), whereas (0.83 [0.56, 1.23], p=0.36). Neither related to measures (p>0.05). Conclusion lower independently slower worse performance. However, predictive these outcomes over 4-8 follow up, exception which after 8 years.